A medical professional has drawn attention to an unusual physical reaction that could signal a significantly elevated cancer risk when consuming alcohol. The response, which appears on the face, may be tied to a genetic mutation affecting alcohol metabolism.

Dr. Karan Rajan referred to this genetic variation as a flaw in the body’s internal “programming.” This mutation—present in about 8% of people globally, with higher prevalence among East Asian populations—impairs the function of the enzyme aldehyde dehydrogenase 2 (ALDH2). Without sufficient ALDH2 activity, the body struggles to eliminate acetaldehyde, a toxic intermediate produced during alcohol breakdown.

As acetaldehyde accumulates, individuals may experience flushed skin, increased pulse, and general discomfort after drinking. According to Dr. Rajan, this physiological reaction may not be just a nuisance—it could serve as a critical indicator of vulnerability to esophageal cancer.

Data from a 2025 study reveal that individuals carrying this mutation may face a dramatically heightened risk—up to 80 times greater—of developing esophageal cancer, even with modest alcohol use. Health authorities stress the importance of recognizing this reaction as more than just a cosmetic effect. Reducing alcohol intake in affected individuals could play a major role in decreasing the likelihood of serious illness.

While facial redness after drinking is often dismissed, it may represent a vital biological alert. Being aware of such genetic traits could empower individuals to make informed choices about alcohol consumption and long-term health.